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  • Title: Intranuclear cytoplasmic invaginations in a Hürthle-cell carcinoma of the thyroid.
    Author: Thranov I, Francis D, Olsen J.
    Journal: Acta Cytol; 1983; 27(3):341-4. PubMed ID: 6575553.
    Abstract:
    According to the literature, the finding of intranuclear cytoplasmic invaginations in fine needle aspiration biopsies from thyroid tumors is indicative of a papillary thyroid carcinoma. A case is presented in which the aspiration specimen showed marked intranuclear cytoplasmic invaginations from a tumor that histologically was a Hürthle-cell (oncocytic) carcinoma with a trabecular pattern. The classification of thyroid carcinomas and the significance of intranuclear cytoplasmic invaginations as a criterion for thyroid malignancy are discussed.
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