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  • Title: [Primary immunologic deficiencies and cancer. 5 anatomo-clinical case reports].
    Author: Mselati JC, Buriot D, Nezelof C.
    Journal: Arch Fr Pediatr; 1983 Mar; 40(3):163-9. PubMed ID: 6576732.
    Abstract:
    Five patients with primary immunodeficiency and cancer are presented. Two children with ataxia-telangiectasia developed acute lymphoblastic leukemia and malignant lymphoma of B-like origin with chromosome damage and unusual prevalence of antibodies to E.B.V. early antigen. A bone sarcoma occurred in a patient with common variable hypogammaglobulinemia. At least two infants who died with severe combined immunodeficiency had at autopsy congenital myelomonocytic leukemia and malignant lymphoma. These cases indicate the high risk for development of cancer in patients with primary abnormalities of the immune system and suggest the heterogeneity and complexity of pathogenic mechanisms.
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