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  • Title: Vascular and secretory effect of adrenoceptor agonists and peptides in the nose.
    Author: Malm L.
    Journal: Eur J Respir Dis Suppl; 1983; 128 (Pt 1)():139-42. PubMed ID: 6578065.
    Abstract:
    With two methods which in cats simultaneously recorded changes of blood flow through the mucosa of a nasal cavity and changes of the nasal patency in the same cavity, it was found that alpha-adrenoceptor agonists and the peptide, angiotensin constricted both the resistance and the capacitance vessels. Beta-adrenoceptor agonists and the peptide VIP dilated the vessels. Further, a filter paper method in dogs demonstrated that a large increase in nasal secretion was obtained with alpha-adrenoceptor stimulation in combination with methacholine, more than that with methacholine alone. Beta-adrenoceptor agonists seem to elicit a very scanty secretion. The peptide, substance P was also found to evoke a nasal secretion.
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