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  • Title: Homogeneously staining regions and double minutes in a human cell line: chromatin organization and DNA content.
    Author: Bahr G, Gilbert F, Balaban G, Engler W.
    Journal: J Natl Cancer Inst; 1983 Oct; 71(4):657-61. PubMed ID: 6578360.
    Abstract:
    Homogeneously staining regions (HSR) and double minutes, two novel chromosome abnormalities, are believed to represent sites of gene amplification. The basic organization of chromatin in an HSR in a human neuroblastoma cell line was shown, by electron microscopy, to be similar to that in a normal chromosome. Double minutes from another human neuroblastoma cell line were found, by dry mass determination, to contain an average of 1.41 X 10(-14) g DNA. This quantity corresponds to 6.38 X 10(3) kilobase DNA per double minute.
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