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  • Title: [Prostaglandins and 3',5'-AMP in rat tissues following administration of thiamine and its derivatives].
    Author: Buko VU, Larin FS, Tarasov IuA, Vinogradov VV.
    Journal: Ukr Biokhim Zh (1978); 1983; 55(4):453-6. PubMed ID: 6578633.
    Abstract:
    The level of prostaglandins and 3':5'-AMP was studied in tissues of albino rats against a background of administering thiamine or its derivatives, oxythiamine and thiochrome. Oxythiamine (12.5 mg per 1 kg of mass; each 3 h for a day) increases the level of a sum of prostaglandins E and A as well as of prostaglandin F2 alpha in the liver and kidneys; thiochrome at the same dose produces the same effect for prostaglandins F and A in the liver and kidneys and for prostaglandin F2 alpha in the liver; and thiamine increases a sum of prostaglandins F and A in the kidneys. 72 h after a single injection of oxythiamine (40 mg per 100 g of mass) the level of prostaglandin E and A sum in the liver and kidneys increases as well, which is not connected with the effect of the substances under study on thiamine-dependent reactions. All the three compounds rise the 3':5'-AMP level in the liver. Variations in the prostaglandin content have no effect on the liver fatty acid composition.
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