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  • Title: [Plasma hormone concentrations in induced abortion with local prostaglandin administration in the 1st trimester].
    Author: Rath W, König A, Ulbrich R, Hilgers R, Kuske R, Kuhn W.
    Journal: Zentralbl Gynakol; 1983; 105(15):961-71. PubMed ID: 6578640.
    Abstract:
    Abortion was performed by curettage on 71 women with pregnancies between the 7th and the 13th week of gestation seven to eight hours after intracervical application of a tylose gel containing 3mg prostaglandin F2 alpha. Prior to the application of the prostaglandin and immediately before the surgical intervention a sonographic examination for determining the vitality of the pregnancy was carried out.--Plasma progesteron, estradiol and HPL levels were determined radioimmunologically prior to the application of prostaglandin, at four-hour intervals on the day of intervention, and 24, 48 and 72 hours after the intervention. In 22 women a complete or an incomplete abortion occurred; in two cases a blighted ovum was observed; 47 pregnancies, according to sonographic examination, remained intact until curettage. After seven to eight hours duration of the effect of the prostaglandin gel, progesterone levels were found to be reduced to 60.5 per cent and 17-beta-estradiol to 31.4 per cent of the initial values, whereas the HPL values fell below the specificity of the testing procedure (12.5 ng/ml). Comparative investigations of the pregnancies which, according to sonographic findings, remained intact until curettage and those which were aborted after the application of prostaglandin did not, in spite of low plasma progesterone and estradiol levels in the abortive group, reveal any statistically significant differences. The abortive effect--even with local application--of the prostaglandins was confirmed. Conclusions regarding the effective mechanism of the prostaglandins upon the fetoplacental unit and the function of the corpus luteum remain subject to speculation. Abortion was performed by curettage on 71 women between weeks 7-13 of gestation 7-8 hours after intracervical application of a tylose gel containing 3 mg prostaglandin F2alpha(PFG2 alpha). Prior to the application of the PG and immediately before surgical intervention, a sonographic examination to determine the vitality of the pregnancy was administered. Plasma progesterone, estradiol, and HPL levels were determined radioimmunologically prior to PG application at 4-hour intervals on the day of intervention, and 24, 48, and 72 hours after intervention. In 22 women, a complete or incomplete abortion occurred; in 2 cases a blighted ovum was observed. 47 pregnancies, according to sonographic examination, remained intact until curettage. After 7-8 hours duration of the effect of PG gel, progesterone levels were reduced to 60.5% and 17 beta-estradiol to 31.4% of the initial values, whereas HPL values fell below the specificity of the testing procedure (12.5 ng/ml). Comparative investigation of the pregnancies, which according to sonographic findings remained intact until curettage and those which were aborted after PG application, did not, in spite of low plasma progesterone and estradiol levels in the abortion group, reveal any statistically significant differences. The abortive effect, even with local application of PGs, was confirmed. Conclusions regarding the effective mechanism of the PGs on the fetoplacental unit and the function of the corpus luteum remain subject to speculation.
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