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  • Title: Morphologic changes in blast cells of children with acute lymphoblastic leukemia in relapse.
    Author: Weinblatt ME, Ortega JA, Kaplan S.
    Journal: Med Pediatr Oncol; 1983; 11(5):339-42. PubMed ID: 6579343.
    Abstract:
    Relapse in children with acute lymphoblastic leukemia (ALL) on therapy may be due to development of a resistant clone of blast cells. Seven children who presented initially with the "common"-type, L1 lymphoblast relapsed with a morphologically different and more undifferentiated blast cell. All were male, with a median age of 12 years at initial presentation. One child who relapsed while off therapy was successfully reinduced and remains in hematologic remission on therapy. The remaining 6 children died within 10 months of relapse. Selection of a resistant clone of lymphoblasts by chemotherapy may be responsible for relapse in children with ALL and should be studied in hopes of controlling the disease.
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