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  • Title: Essential hypertension and membrane lithium transport in depressed patients.
    Author: Mallinger AG, Mallinger J, Himmelhoch JM, Rossi A, Hanin I.
    Journal: Psychiatry Res; 1983 Sep; 10(1):11-6. PubMed ID: 6580654.
    Abstract:
    Na+-Li+ countertransport activity in erythrocytes has previously been reported to be decreased in certain patients with mood disorders, but increased in essential hypertensives and possibly their first-degree relatives. The present investigation examines specific parameters of Na+-Li+ countertransport in relation to both affective disorder and essential hypertension. Depressed patients having a personal or family history of essential hypertension had significantly higher Vmax and fractional lithium release values than did other patients or control subjects. Values of K 1/2 did not differ among the groups. Essential hypertension in experimental subjects or their families may complicate attempts to study human erythrocyte (RBC) lithium transport in depressed patients.
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