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  • Title: [Experimental and clinical evaluation of cefotetan in pediatrics].
    Author: Aoyama R, Kakizaki Y, Ohnishi A, Izumi Y, Fujita M, Nagata K, Asuka N, Kudo M, Chiba C, Tsushima N.
    Journal: Jpn J Antibiot; 1983 Jun; 36(6):1191-8. PubMed ID: 6581325.
    Abstract:
    Basic and clinical studies on cefotetan (CTT) were carried out and the results were as follows: Absorption and excretion Two patients were given 10 mg/kg of CTT by one shot intravenous injection. At 30 minutes after injection, mean serum level was 76.5 micrograms/ml and the half-life time was 2.3 hours. Mean 6-hour urinary recovery in same patients was 57.5%. Clinical evaluation Forty-two patients were treated with CTT, in doses of 19.2-102.9 mg/kg divided 2-4 times per day for 3-10 days intravenously. Responses were excellent in 14, good in 23, fair in 1, poor in 4, and the overall efficacy rate was 88.1%. As to adverse reaction, urticaria was observed in 1 patient. Abnormal laboratory data noted were elevation of GOT in 1, GOT and GPT in 2, creatinine in 1, and eosinophilia in 3 patients.
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