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  • Title: 3H-Apomorphine interactions with dopamine receptors in calf brain.
    Author: Thal L, Creese I, Snyder SH.
    Journal: Eur J Pharmacol; 1978 Jun 01; 49(3):295-9. PubMed ID: 658143.
    Abstract:
    3H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, 3H-apomorphine interacts with receptors in a manner more like 3H-dopamine than 3H-haloperidol. These properties of 3H-apomorphine binding are those of an apparently "pure" agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase.
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