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  • Title: [Cysteine activity in the poisoning of animals by various aliphatic series halogenated hydrocarbons].
    Author: Bakhishev GV.
    Journal: Farmakol Toksikol; 1978; 41(3):342-4. PubMed ID: 658385.
    Abstract:
    In poisoning animals with various aliphatic series haloid-hydrocarbons (LK99 and LD99) free cysteine was found to be a group antidote in rats poisoned with monohaloid-hydrocarbons. It was established that the therapeutic activity of cystein depends not on the nature of haloid and double bonds, but on the number of the haloid atoms in a molecule, the length, ramification and nature of the radical. A good durative action are shown by such cystein derivatives as acetyl-cysteine, glutathione and cystein salts. In poisoning with haloid-alkyls dithiol antidotes (unithiol, mecaptide, BAL) and other drugs proved ineffective.
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