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  • Title: Serum C-reactive protein levels in the management of infection in acute leukaemia.
    Author: Starke ID, de Beer FC, Donnelly JP, Catovsky D, Goldman JM, Galton DA, Pepys MB.
    Journal: Eur J Cancer Clin Oncol; 1984 Mar; 20(3):319-25. PubMed ID: 6584311.
    Abstract:
    C-reactive protein (CRP) was measured serially in 29 patients with acute leukaemia. Sixty-four febrile episodes (greater than or equal to 38 degrees C) occurred during 37 periods of neutropenia (less than 0.5 X 10(9)/l). In all of 41 microbiologically or clinically documented infections the maximum CRP level exceeded 30 mg/l, and in 25 it was greater than 100 mg/l. In no case in which the CRP level remained below 30 mg/l for 48 hr after the onset of fever was any clinical or microbiological evidence of infection obtained. The CRP level during documented infection began to fall 24-48 hr after appropriate treatment was begun. A CRP level above 30 mg/l in neutropenic patients was associated with early recurrence of fever if systemic antibiotics were discontinued. Graft-vs-host disease, without infection, did not result in high levels of CRP.
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