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  • Title: Decreased fibronectin biosynthesis by human cord blood mononuclear phagocytes in vitro.
    Author: Gerdes JS, Douglas SD, Kolski GB, Yoder MC, Polin RA.
    Journal: J Leukoc Biol; 1984 Jan; 35(1):91-9. PubMed ID: 6584514.
    Abstract:
    Cultured cord blood monocytes synthesize significantly less fibronectin than cultured monocyte-macrophages from adult peripheral blood. Biosynthesis of the second component of complement in vitro is similar for both cell systems. The monocyte-macrophages from neonates and adults have similar functional and morphologic properties in long-term cultures. The decreased monocyte-macrophage biosynthesis of fibronectin observed in vitro may be in part related to the reduced plasma fibronectin concentrations and reticuloendothelial system hypofunction which occur in newborn infants.
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