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  • Title: New synthetic and natural tuftsin-related compounds and evaluation of their phagocytosis-stimulating activity.
    Author: Martinez J, Winternitz F.
    Journal: Ann N Y Acad Sci; 1983; 419():23-34. PubMed ID: 6585171.
    Abstract:
    The preparation of large amounts of tuftsin (50 g) as well as purification by preparative HPLC are presented. Synthesis of several analogues exhibiting significant phagocytosis-stimulating activity of human PMN are described and discussed. On the other hand, the synthesis of a natural human IgG decapeptide fragment 335-344 that could be liberated from the same carrier molecule is presented. This decapeptide fragment, Thr-Ile-Ser-Lys-Ala-Lys-Gly-Gln-Pro-Arg, showed interesting activity in stimulating phagocytosis of human polymorphonuclear leukocytes.
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