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  • Title: Acute myelomonocytic leukemia with involvement of eosinophils and inversion of chromosome 16.
    Author: Schmitz N, Gödde-Salz E, Gassmann W, Löffler H.
    Journal: Blut; 1984 May; 48(5):263-7. PubMed ID: 6586212.
    Abstract:
    A case of acute nonlymphocytic leukemia (ANLL) with abnormal marrow eosinophils is presented. Thorough morphological, cytochemical, and cytogenetic studies confirm the existence of a recently defined new cytogenetic-morphological entity: acute myelomonocytic leukemia with abnormal bone marrow eosinophils (FAB M4), chloracetate esterase- and periodic acid-Schiff-positivity of eosinophilic granules, and pericentric inversion of chromosome 16, in this case combined with trisomy 8. So far 18 such cases have been reported from a single institution. The implications of this new association on the diagnosis of acute leukemia with abnormal eosinophils are discussed.
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