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  • Title: Coexistence of cells with unmasked and masked Ph1 in a case of chronic myeloid leukemia in blastic phase.
    Author: Pedersen B.
    Journal: Cancer Genet Cytogenet; 1984 Jun; 12(2):129-37. PubMed ID: 6586280.
    Abstract:
    Bone marrow from a patient with chronic myeloid leukemia in blastic phase at diagnosis showed cells with t(9;22), as well as others with a 22q+ marker. The marker was due to t(8;22), and consequently, these cells presented a masked Ph1: t(8;9;22) (q24.2;q34;q11). The marrow contained a wide variety of abnormal clones, which formed an evolutionary pedigree. The pedigree allowed location of the stage of evolution at which masking of the Ph1 had taken place.
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