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  • Title: Inhibition of ovulation in rats with epostane, an inhibitor of 3 beta-hydroxysteroid dehydrogenase.
    Author: Snyder BW, Beecham GD, Schane HP.
    Journal: Proc Soc Exp Biol Med; 1984 Jul; 176(3):238-42. PubMed ID: 6587400.
    Abstract:
    Epostane (Win 32729), an inhibitor of the 3 beta-hydroxysteroid dehydrogenase enzyme system, inhibited both spontaneous and pregnant mare's serum/human chorionic gonadotropin-induced ovulation in rats. When administered on the morning of proestrus, the drug blocked pregnancy in females that were inseminated that evening. The blockage of pregnancy occurred at a dose of 200 mg/kg but not at 50 mg/kg. Similarly, when administered on the morning of proestrus at a dose of 200 mg/kg, epostane inhibited the appearance of ova in the oviducts the next day. In gonadotropin-primed immature rats, epostane inhibited ovulation in a dose-related fashion with an ED50 between 25 and 50 mg/kg. The drug also decreased plasma progesterone levels in these animals. The inhibitory effect of epostane on gonadotropin-stimulated ovulation was reversed by injections of progesterone at a total daily dose of 6.25 mg/rat or greater. These results support the contention that steroidogenesis, specifically progesterone synthesis, is a prerequisite to ovulation.
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