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  • Title: Interferon fever: absence of human leukocytic pyrogen response to recombinant alpha-interferon.
    Author: Ackerman SK, Hochstein HD, Zoon K, Browne W, Rivera E, Elisberg B.
    Journal: J Leukoc Biol; 1984 Jul; 36(1):17-25. PubMed ID: 6588130.
    Abstract:
    A sensitive in vitro assay for generation of human leukocytic pyrogen has been used to study the pathogenesis of fever accompanying administration of human alpha-interferon. Unlike other potent pyrogens, two recombinant interferon preparations tested over a wide concentration range did not stimulate release of leukocytic pyrogen. This result suggests that interferon may cause fever by a novel mechanism not dependent on leukocytic pyrogen.
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