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  • Title: [Inhibitory effect of cholesterol on changes in membrane permeability and potential induced with lysolecithin in red blood cells (author's transl)].
    Author: Shinozawa S, Araki Y, Utsumi K.
    Journal: Nihon Yakurigaku Zasshi; 1978 Mar; 74(2):297-302. PubMed ID: 658841.
    Abstract:
    Membrane stabilizing effects of cholesterol on the permeability of K+ and change in membrane potential induced with lysolecithin were investigated. Cholesterol inhibited K+ release from rabbit red blood cells treated with lysolecithin. 3.3 X 10(-6)M of cholesterol was the optimum concentration required to inhibit K+ release from rabbit red blood cells treated with lysolecithin (1.25 microgram/ml) at the level of 100 percent. Change in membrane potential was evident with lysolecithin by the method of fluorescent dye and, cholesterol inhibited the change which was dose dependent. These inhibitory effects of cholesterol on the K+ release and changes in membrane potential served as the membrane stabilizing action on red blood cell membrane. It is assumed that cholesterol acts as an inhibitor to increase membrane fluidity and permeability of malignant transformed cells such as tumor and lymphoid cells.
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