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  • Title: Intragastric bile acid and lysolecithin in gastroduodenal ulcer and gastric cancer.
    Author: Schumpelick V, Stemme D, Hofmann G, Begemann F.
    Journal: Scand J Gastroenterol Suppl; 1984; 92():172-7. PubMed ID: 6588509.
    Abstract:
    In 99 patients with different types of gastroduodenal ulcer and gastric carcinoma the intragastric concentrations of bile acids and lysolecithin was analyzed under fasting, basal and pentagastrin-stimulated conditions. Normal concentrations were found in type III gastric ulcer (prepyloric). There was a three- to four fold increased reflux concentration in the mean of patients with gastric ulcer type I but some patients showed normal values too. The calculated reflux rate was also slightly elevated. In duodenal ulcer normal concentrations could be observed with the exception of a slight increase under fasting conditions. In gastric carcinoma of the proximal half normal reflux concentrations were found. Distal gastric carcinoma was associated with a two- to three-fold increase of bile acids as well as lysolecithin concentration. The same was found concerning the reflux rate. Our results demonstrated a comparable low increase of duodenogastric reflux concentration in proximal gastric ulcer and distal gastric carcinoma. They give no evidence for a major role of reflux in the pathogenesis of gastroduodenal ulcer.
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