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  • Title: The patas monkey as a model for dihydrostreptomycin ototoxicity.
    Author: Hawkins JE, Stebbins WC, Johnsson LG, Moody DB, Muraski A.
    Journal: Acta Otolaryngol; 1977; 83(1-2):123-29. PubMed ID: 65898.
    Abstract:
    Although the cochlear toxicity of dihydrostreptomycin (DHSM) is well-recognized in man, it has always proved difficult to demonstrate in animals. Hearing thresholds in M. nemestrina monkeys remained essentially unchanged after DHSM 100 mg/kg im daily for 8 months, but E. patas monkeys were severely deafened by DHSM 20 mg/kg for 90 days, a regimen formerly used in treating human tuberculosis. The patas monkey may prove to be the animal model of choice for evaluating aminoglycoside ototoxicity.
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