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  • Title: Differential effect of the rd mutation on rods and cones in the mouse retina.
    Author: Carter-Dawson LD, LaVail MM, Sidman RL.
    Journal: Invest Ophthalmol Vis Sci; 1978 Jun; 17(6):489-98. PubMed ID: 659071.
    Abstract:
    The retinas of rd/rd C57BL/6J-rd le mice have been examined by light and electron microscopy to determine whether rod cell degeneration precedes cone cell degeneration. In all regions of the eye, a rapid rod degeneration precedes a much slower cone degeneration. Only about 2% of the rods remain in the posterior region at postnatal day 17, and none by the day 36. By contrast, at least 75% of the cone nuclei remain at day 17. Although most of these slowly disappear, about 1.5% of the original population of cone nuclei in the posterior retina is still present at 18 months of age. A central to peripheral temporal gradient of degeneration exists, such that some rod nuclei persist in the far periphery up to day 47, but none is found at day 65. About 5% of the cone nuclei are still present in the far periphery at 18 months of age.
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