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  • Title: Clinical and biochemical findings in Leber's hereditary optic atrophy.
    Author: Syme IG, Bronte-Stewart J, Foulds WS, McClure E, Logan R, Stansfield M.
    Journal: Trans Ophthalmol Soc U K (1962); 1983; 103 ( Pt 5)():556-9. PubMed ID: 6591596.
    Abstract:
    Clinical findings in Leber's hereditary optic atrophy (LHOA) are reviewed and the results given of treatment with a regimen based on the hypothesis that the disease is a manifestation of cyanide toxicity. Recent biochemical investigations confirm disturbed cyanide metabolism and suggest that zinc deficiency may be implicated.
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