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  • Title: Antibodies against osteosarcoma and colon cancer.
    Author: Embleton MJ, Brown A, Gunn B, Byers VS, Baldwin RW.
    Journal: Behring Inst Mitt; 1984 May; (74):35-8. PubMed ID: 6591916.
    Abstract:
    Two monoclonal antibodies with anti-human tumour reactivity were produced by murine hybridomas. One, 791T/36, is an IgG2b which was raised against a cultured human osteogenic sarcoma cell line, 791T. This antibody reacts with a high proportion of osteogenic sarcomas, and also with other tumour types. It has been used successfully as a tumour localising antibody in vivo and a targeting agent in vitro. The other antibody, C14/1/46, was raised against a human colonic adenoma. An IgM antibody, it reacts with most colorectal carcinoma cells but only with a small subpopulation of cells within the normal mucosa. It has been shown to recognise a difucosylated Type-2 blood-group chain, which has raised expression in colorectal carcinoma tissue.
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