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  • Title: HLA-linked SB antigens in Israel. Population study, analysis of homozygous typing cells and generation of local SB reagents.
    Author: Cohen N, Shaw S, Amar A, Oksenberg J, Brautbar C.
    Journal: Tissue Antigens; 1984 Aug; 24(2):113-20. PubMed ID: 6593897.
    Abstract:
    In the present study we have investigated the HLA-SB antigen distribution in 65 unrelated Israeli Ashkenazim and non-Ashkenazim and in a panel of 18 local homozygous typing cells (HTC). Two locally derived SB reagents, anti-SB2 and SB3, were also studied. The HLA-SB allele frequencies in the Israeli sample ranged from 0.02 for SB1 to 0.47 for SB4 while SB5 was absent. SB3 had a higher frequency in non-Ashkenazim (0.11) as compared to Ashkenazim (0.06) but this difference was not significant. On the whole, the allele frequencies for the 5 HLA-SB antigens studied were in the range observed in non-Jewish Caucasoid populations with some minor variations. Two of eighteen local HTC's were found heterozygous for SB, demonstrating that homozygosity for HLA-A, B, C, D and DR does not indicate homozygosity for HLA-SB. The local anti-SB2 and SB3 typing reagents gave concordant results when compared with the NIH reference typing cells in population studies.
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