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  • Title: Studies on ovarian prostaglandin production in relation to ovulation in the rat.
    Author: Brown CG, Poyser NL.
    Journal: J Reprod Fertil; 1984 Nov; 72(2):407-14. PubMed ID: 6595406.
    Abstract:
    Prostaglandin (PG) and thromboxane (TX) synthesizing capacities of the rat ovary were measured at 4-h intervals during the 4-day oestrous cycle of the rat. Production of PGE-2, PGF-2 alpha, 6-oxo-PGF-1 alpha and TXB-2 increased 5-fold, 1.6-fold, 1.7-fold and 1.7-fold, respectively, between 18:00 h on the day of pro-oestrus and 02:00 h at oestrus. This preferential stimulation of ovarian PGE-2 production, after the ovulatory surge of LH before ovulation, provides further evidence for the involvement of ovarian PGE-2 in ovulation in the rat. These increases in ovarian PG production were not due to differences in arachidonic acid availability, PG metabolism, or the interconversion of PGE-2 and PGF-2 alpha. In addition, the greater stimulation of PGE-2 synthesis was not due to an increase in PGH-2 to PGE-2 synthetase activity. It is concluded that the ovulatory LH surge late in the afternoon of pro-oestrus in the rat causes an increase in ovarian cyclo-oxygenase (PGH-2 synthetase) activity with the majority of the PGH-2 synthesized being directed into the PGE-2-forming pathway.
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