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  • Title: Prostaglandin-induced eosinopenia in splenectomized rats.
    Author: Kurosawa M, Nemoto T, Aoki H, Ike A, Abe O, Sunaga Y, Kobayashi S.
    Journal: J Allergy Clin Immunol; 1978 Jul; 62(1):33-6. PubMed ID: 659738.
    Abstract:
    PGE1, PGE2, and PGF2alpha over a dose range of 1 to 50 microgram/kg decreased the number of circulating eosinophils in splenectomized rats. Pretreatment with a beta-blocking agent, propranolol, did not alter this effect, but adrenalectomy eliminated it. Anterior hypothalamic destruction also abolished eosinopenia induced by PGE1 and PGF2alpha but not that induced by PGE2.
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