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  • Title: [Prevention of ocular toxicity of ethambutol: study of zincaemia and chromatic analysis (author's transl)].
    Author: Delacoux E, Moreau Y, Godefroy A, Evstigneeff T.
    Journal: J Fr Ophtalmol; 1978 Mar; 1(3):191-6. PubMed ID: 659802.
    Abstract:
    In order to define the means of prevention of the ocular toxicity of ethambutol (EMB), 72 patients under treatment with EMB-INH-Rifampicin combination were subjected to systematic analysis of plasma, blood and urinary zinc levels together with a full ophthalmic examination. Comparison of the results from 12 patients sustaining ocular damage at the time of treatment with the results of 60 others: 1) demonstrates the existence of a correlation between plasma zinc levels before treatment and the probability of ocular damage from EMB (high risk for zinc is less than 0.70 mg/l - almost no risk for zinc greater than 1 mg/l); 2) confirms that dyschromatopsia is one of the first signs of ocular damage through EMB and thus constitutes an alarm signal; 3) suggests that the ocular toxicity of EMB might appear in the retina before the optic nerve.
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