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  • Title: Suppression of the sympathetic nerve activity after surgical reversal of two-kidney, one clip hypertension in rats.
    Author: Göthberg G, Thorén P.
    Journal: J Hypertens Suppl; 1984 Dec; 2(3):S355-7. PubMed ID: 6599681.
    Abstract:
    The change in tonic renal efferent sympathetic nerve activity (RSNA) was studied during the rapid fall in mean arterial pressure (MAP) after surgical reversal of two-kidney, one clip hypertension in rats (RHR). Controls used were intact RHR exposed to the same fall in MAP induced by slow infusion of sodium nitroprusside. Within 2 h after declipping, MAP had fallen from 191 +/- 9 mmHg to 106 +/- 8 mmHg. During this decline in pressure, the reflex increase in RSNA, ordinarily following a decrease in pressure, was clearly suppressed; after a short and transient initial increase, RSNA was below the control level. In comparison, upon vascular dilatation with sodium-nitroprusside, the same fall in MAP was accompanied by a 117 +/- 30% increase in RSNA (P less than 0.01). Thus, the rapid normalization of MAP after reversal of renovascular hypertension involves a mechanism that exerts a suppressive action on the efferent sympathetic activity.
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