These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Soluble factors for B cell activation: a T cell hybridoma that secretes a specific B cell growth factor.
    Author: Garchon HJ, Levi-Strauss M, Carnaud C, Bach JF.
    Journal: J Immunol; 1983 Feb; 130(2):777-80. PubMed ID: 6600254.
    Abstract:
    A murine T cell hybridoma, T91, has been established by fusion of BALB/c Con A-activated spleen cells with BW 5147 HAT-sensitive thymoma cells. T91 constitutively produced a factor that markedly enhanced the proliferative response to LPS of B cells cultured at low cell density. This factor is nonmitogenic by itself. It maintains in the absence of LPS, the proliferation of B cell blasts previously activated with LPS for 3 days. T91 supernatant contains neither IL 1 nor IL 2 nor TRF activity, and mixing experiments indicate the absence of factors suppressing these activities. The data suggest the existence of a specific B cell growth factor compatible with a two-signal model for B lymphocyte activation.
    [Abstract] [Full Text] [Related] [New Search]