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  • Title: Analysis of the primary translational product and integrated DNA of a new feline sarcoma virus, GR-FeSV.
    Author: Naharro G, Dunn CY, Robbins KC.
    Journal: Virology; 1983 Mar; 125(2):502-7. PubMed ID: 6601328.
    Abstract:
    The Gardner-Rasheed strain of feline sarcoma virus (GR-FeSV), is a recent isolate of a naturally occurring cat sarcoma. The primary translational product of GR-FeSV (GR P70) was shown to be a phosphoprotein with associated tyrosine-specific protein kinase activity. The relationship between the GR-FeSV provirus and once genes of other transforming retroviruses known to code for tyrosine kinases was examined by molecular hybridization. Probes repesenting onc genes of Snyder-Theilen and McDonough strains of feline sarcoma virus, Rous sarcoma virus, and Abelson murine leukemia virus did not detectably hybridize integrated GR-FeSV. These findings suggest that GR-FeSV contains a distinct tyrosine kinase-coding onc gene.
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