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  • Title: Impaired production of interleukins in patients with cell-mediated immunodeficiencies.
    Author: Paganelli R, Aiuti F, Beverley PC, Levinsky RJ.
    Journal: Clin Exp Immunol; 1983 Feb; 51(2):338-44. PubMed ID: 6601554.
    Abstract:
    The poor mitogen response to phytohaemagglutinin (PHA) of lymphocytes from three patients with cell-mediated immunodeficiencies was restored to normal when supernatants containing interleukin 2 (IL-2) were added. One of three children with severe combined immunodeficiency also showed a partial response. There was no improvement in the normal mitogenic response of the lymphocytes from patients with either the X linked or common variable forms of hypogammaglobulinaemia. All three patients with cell-mediated immunodeficiencies showed gross imbalance in the ratio of helper/inducer (OKT4+) to suppressor/cytotoxic (OKT8+) T cells. The PHA stimulated culture supernatant from one of these patients failed to induce proliferation of a cytolytic continuous T cell line. Our data suggests that the underlying defect in these patients may be a failure in production of interleukins but not in the acquisition of IL-2 receptors.
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