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  • Title: Rheumatoid arthritis in a Chippewa band. II. Field study with clinical serologic and HLA-D correlations.
    Author: Harvey J, Lotze M, Arnett FC, Bias WB, Billingsley LM, Harvey E, Hsu SH, Sutton JD, Zizic TM, Stevens MB.
    Journal: J Rheumatol; 1983 Feb; 10(1):28-32. PubMed ID: 6601712.
    Abstract:
    We present an in-depth study of rheumatoid arthritis (RA) in a Chippewa band. Of the 227 band members, 168 (74%) were evaluated. The unusually high prevalence of RA was confirmed in 7.1% of those studied or, minimally, 5.3% with a 100% completion rate without additional cases found. Seropositivity in those with clinically definite RA was 92% relative to rheumatoid factor and 75% for ANA. Despite the high prevalence (68%) of HLA-DR4 in this closed population, there was a significant correlation of DR4 with RA (100%). The implications of these observations in this population isolate are discussed.
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