These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Subsets of oncofetal antigen-induced T-cells: ability to mediate antitumor immune response. Author: Gautam S, Deodhar SD. Journal: J Natl Cancer Inst; 1983 May; 70(5):923-30. PubMed ID: 6601736. Abstract: The present study was performed to identify the subsets of oncofetal antigen-induced T-cells that mediate antitumor immune response in mice. In this study, performed on a weakly immunogenic, metastatic tumor, fetal antigen-sensitized spleen cells significantly inhibited the growth and metastases of tumors in Winn neutralization assay. Mixing of spleen cells from tumor-bearing inbred C57BL/6J mice with fetal antigen-sensitized spleen cells completely abolished the tumor inhibitory effect of fetal antigen-sensitized spleen cells. Further characterization of fetal antigen-sensitized spleen cells showed that they were Thy-1+. These findings reveal that tumor-associated fetal antigens on fetal cells can produce a tumor inhibitory T-cell immune response against the growth and metastases of a weakly immunogenic, metastatic tumor. The subset of oncofetal antigen-induced T-cells that mediates antitumor immune response was identified as Lyt-1+ and Lyt-2-. Adoptive transfer of fetal antigen-sensitized spleen cells to mice with preestablished metastases significantly inhibited the lung metastases in these mice, thus making this approach more relevant to a clinical situation in cancer patients.[Abstract] [Full Text] [Related] [New Search]