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  • Title: A report of a case of T-cell-derived chronic lymphocytic leukemia with antibodies to adult T-cell leukemia-associated antigens.
    Author: Utsunomiya A, Matsumoto M, Matsumoto T, Nishioka K, Iwahashi M, Hanada S, Nomura K, Hashimoto S, Yunoki K.
    Journal: Jpn J Clin Oncol; 1983; 13 Suppl 2():291-9. PubMed ID: 6603537.
    Abstract:
    A case of T-cell-derived chronic lymphocytic leukemia (T-CLL) with antibodies to adult T-cell leukemia (ATL)-associated antigens (ATLA) is reported. The patient had marked lymphocytosis consisting of peripheral cells that were shown to be T cells by their spontaneous sheep erythrocyte rosette formation and their OKT3 and OKT8 positivity, and in which ATLA were also detected after short-term culture of the cells in vitro. These findings suggest that adult T-cell leukemia virus (ATLV) might cause not only ATL but also some other lymphoid malignancies such as a type of T-CLL as in this case report. Nevertheless the occasional development of OKT8-positive T-CLL in a healthy carrier of ATLV in an ATL-endemic area cannot be disregarded.
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