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  • Title: Generation mechanism of the negative endocochlear potential during early stage of anoxia.
    Author: Kusakari J, Rokugo M, Kambayashi J, Arakawa E, Ohyama K, Hara A, Kawamoto K.
    Journal: ORL J Otorhinolaryngol Relat Spec; 1983; 45(4):195-202. PubMed ID: 6603600.
    Abstract:
    To investigate the generation mechanism of the -EP in anoxic cochlea, the perilymphatic space was perfused with solution of various K+ concentrations in 38 guinea pigs when the -EP was maximally reduced by anoxia. Although the perfusion of scala tympani and vestibuli with Ringer-Locke solution or that of scala vestibuli with 154 mM K+ solution did not have any effect upon the -EP, the potential was elevated to 0 mV when the scala tympani was perfused with 154 mM K+ solution. Furthermore, the elevation of the potential was less remarkable when the K+ concentration in perfusate was reduced. The level of the potential during perfusion was closely related to K+ concentration in perfusates. The present results strongly suggest that the -EP is the result of the K+ diffusion potential and this diffusion mechanism is performed through the organ of Corti.
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