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  • Title: Hypnotic effects of deoxycorformycin in rats.
    Author: Radulovacki M, Virus RM, Djuricic-Nedelson M, Green RD.
    Journal: Brain Res; 1983 Jul 25; 271(2):392-5. PubMed ID: 6604561.
    Abstract:
    Rats implanted with EEG and EMG electrodes were treated with deoxycoformycin (0.5 or 2.0 mg/kg, i.p.), and polygraphically recorded for 6 h. Deoxycoformycin is a potent inhibitor of adenosine deaminase and would be expected to elevate the levels of adenosine in the central nervous system. The 0.5 mg/kg dose of the drug increased REM sleep and reduced REM sleep latency while the dose of 2.0 mg/kg increased deep slow-wave sleep (S2). These results appear to be consistent with those reported previously for the adenosine analog, N6-(L-phenylisopropyl)-adenosine (L-PIA) and indicate a hypnotic role for adenosine.
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