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  • Title: DR antigen distribution in Blacks with rheumatoid arthritis.
    Author: Alarcón GS, Koopman WJ, Acton RT, Barger BO.
    Journal: J Rheumatol; 1983 Aug; 10(4):579-83. PubMed ID: 6604813.
    Abstract:
    DR antigen distribution was studied in 85 Blacks with either classical or definite rheumatoid arthritis (RA). Sixty-three were seropositive and 22 were seronegative by latex fixation titer. The frequency of DR4 was 7.41% in our control Black population (n = 162), 22.22% in the seropositive (0.01 greater than p greater than 0.001; RR 3.57) and 22.72% in the seronegative RA (0.01 greater than p greater than 0.001; RR 3.67). Our data confirm the association of DR4 with seropositive RA in Blacks, and suggest a similar association of DR4 with seronegative RA. It also suggests that DR4 may be a risk factor for more aggressive disease in Blacks with seropositive RA.
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