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  • Title: Ankylosing spondylitis: a family study.
    Author: LeClercq SA, Chaput L, Russell AS.
    Journal: J Rheumatol; 1983 Aug; 10(4):629-32. PubMed ID: 6604814.
    Abstract:
    Of the first degree relatives of B27 positive spondylitis probands, 10.2% demonstrated an associated disease, i.e., ankylosing spondylitis, Reiter's syndrome, peripheral arthritis, or acute anterior uveitis; all were B27 positive. Eighteen, i.e., only 13.7% of the B27 positive subjects had sacroiliitis; 4 were asymptomatic. We would therefore caution against the previous over-estimation of disease prevalence in "randomly selected" HLA-B27 positive individuals. None of the B27 negative relatives had any uveitis or spondyloarthropathy.
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