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  • Title: [Correlation between the T, K and NK cell count and the IgE level in patients with atopy (pollinosis)].
    Author: Gushchin IS, Leskov VP, Chitaeva VG, Polsacheva OV, Poroshina IuA.
    Journal: Vutr Boles; 1983; 22(1):50-8. PubMed ID: 6605625.
    Abstract:
    In a homogenous group of patients with polyposis, IgE level was juxtaposed to the number of E-rosette-forming cells (E-RFC), K- and NK-cells. The effect of a parenterally introduced allergen (via an accelerated course hyposensibilization) was also determined upon those indices. The number of E-RFC was diminished in the patient group (53,1 +/- 3,3%) as compared with the results (67,2 +/- 2,1%) obtained from the control subjects, selected by the control method of couples. A dependence of a direct ratio was found between the number of E-RFC and IgE level in the patients. The number of K- and NK-cells in the patients did not significantly differ from their number in the control subjects; no relationship was found between the number of K-cells and the number of NK-cells, between those cells and IgE level or the number of E-RFC. Allergen-specific cells - kilers were present in the peripheral blood of the patients with polyposis. The course of specific hyposensibilization carried out was accompanied, in all patients by increased number of E-RFC (to 122 +/- 7% as compared with the initial level) and a reduction of the number of K-cells (to 36 +/- 5.4% as compared with the initial level). Both the changes in IgE level and the number of NK-cells were not of one type in all patients.
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