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  • Title: Plasma concentrations of vitamin D metabolites in a case of rickets of prematurity.
    Author: Markestad T, Aksnes L, Finne PH, Aarskog D.
    Journal: Acta Paediatr Scand; 1983 Sep; 72(5):759-61. PubMed ID: 6605658.
    Abstract:
    Rickets was diagnosed in an extremely low-birthweight infant 16 weeks after birth. She had a normal plasma concentration of 25-hydroxyvitamin D, a relatively low level of 24,25-dihydroxyvitamin D, and a markedly elevated 1,25-dihydroxyvitamin D level compared with adult standards. The plasma concentrations of the vitamin D metabolites were, however, indistinguishable from those of healthy preterm infants who received a similar diet of human milk and vitamins. The results indicate that rickets was not caused by vitamin D deficiency or by abnormal vitamin D metabolism, but by calcium and/or phosphate deficiency, and that the calcium and phosphorous content of human milk may be inappropriately low for very low-birthweight infants.
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