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  • Title: Imbalance in T-cell subsets of five children with congenital agammaglobulinemia and its effect on "in vitro" immunoglobulin synthesis.
    Author: De Martino M, Rossi ME, Pratesi F, Vierucci A.
    Journal: Boll Ist Sieroter Milan; 1983 Jul; 62(3):273-80. PubMed ID: 6605756.
    Abstract:
    OKT3, OKT4 and OKT8 monoclonal antibodies have been used to assess the number of total T cells and of some T-cell subpopulations in five children with Congenital Agammaglobulinemia. A significant increase in OKT8+ cells and parallel decrease in OKT4+ cells were observed in all patients, both as percentages and absolute numbers. by contrast there was no significant difference in the number of total T cells (OKT3+) and OKT3+ OKT4- OKT8- cells between patients and controls. Determinations were made of the synthesis of IgG and IgM by normal B cells cultured with T lymphocytes from patients stimulated by pokeweed mitogen. In all cases a significant decrease in Ig synthesis was observed. These results may be consistent with imbalance in the T regulatory subsets. However, a similar imbalance was observed in a healthy father of one patient, who had no other immunological defect. A normal distribution of T-cell subsets was observed in all the other relatives examined.
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