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  • Title: Accessory cell function of liver granuloma macrophages of Schistosoma mansoni-infected mice.
    Author: Schook LB, Wellhausen SR, Boros DL, Niederhuber JE.
    Journal: Infect Immun; 1983 Dec; 42(3):882-6. PubMed ID: 6605931.
    Abstract:
    In murine schistosomiasis mansoni, the inflammatory macrophage comprises 30% of the granuloma which forms around parasite eggs in the tissue. These granuloma macrophages (GR-Mphi) displayed dense Fc and C3 receptors, and about 50% expressed H-2I region-encoded determinants (Ia antigens). These GR-Mphi were able to effectively reconstitute the burro erythrocyte-specific immunoglobulin M and G antibody response of primed macrophage-depleted spleen cells. However, in contrast to splenic macrophages, GR-Mphi gave only minimal reconstitution of the primary immunoglobulin M response. The reconstitution of the T-cell proliferative response to L-glutamic60-L-alanine30-L-tyrosine10, an antigen under Ir gene control, was also observed when GR-Mphi were added to purified lymph node T-cells. The addition of a monoclonal antibody recognizing a determinant on the Ia complex effectively blocked L-glutamic60-L-alanine30-L-tyrosine10 presentation by GR-Mphi. These studies demonstrated that inflammatory GR-Mphi could function as antigen-presenting cells and that this accessory function was mediated by H-2I region gene products.
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