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  • Title: Synthesis and hypoglycemic activity of some substituted 2-arylthiazolo[3,2-a]pyridinium salts.
    Author: Blank B, DiTullio NW, Krog AJ, Saunders HL.
    Journal: J Med Chem; 1978 May; 21(5):489-92. PubMed ID: 660598.
    Abstract:
    A series of substituted 2-arylthiazolo[3,2-a]pyridinium salts (1a-q) was prepared by known methods and tested for hypoglycemic activity in 48-h fasted rats. Two compounds, 2-phenylthiazolo- and 8-methyl-2-phenythiazolo[3,2-a]pyridinium perchlorate (1a and 1q), showed consistent hypoglycemic activity in this screen, demonstrating that a high degree of structural specificity was required for hypoglycemic activity. At higher doses the hypoglycemic activity of 1a and 1q was associated with elevated levels of hepatic triglycerides.
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