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  • Title: Amiodarone-induced hypersensitivity pneumonitis. Evidence of an immunological cell-mediated mechanism.
    Author: Akoun GM, Gauthier-Rahman S, Milleron BJ, Perrot JY, Mayaud CM.
    Journal: Chest; 1984 Jan; 85(1):133-5. PubMed ID: 6606534.
    Abstract:
    Interstitial pneumonitis developed in a patient who had received a cumulative dose of 985 g of amiodarone in nine years. No other cause for pneumonitis was found. The following findings favor an immunologic mechanism of hypersensitivity due to amiodarone: positive skin and basophil degranulation tests with amiodarone; lymphocytosis and inverted ratio of helper/suppressor T lymphocytes in bronchoalveolar lavage fluid; secretion of leukocyte inhibitory factor, as shown by the inhibition of migration of peripheral blood leukocytes; and positive lymphoblastic transformation in the presence of amiodarone.
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