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  • Title: ATP-stimulated accumulation of calcium by chromaffin granules and mitochondria from the adrenal medulla.
    Author: von Grafenstein HR, Neumann E.
    Journal: Biochem Biophys Res Commun; 1983 Nov 30; 117(1):245-51. PubMed ID: 6607051.
    Abstract:
    In the presence of high concentrations of free Ca2+ (10(-5) - 10(-4) M) chromaffin granules and adrenal medullary mitochondria take up large amounts of Ca2+. At low levels of buffered free Ca2+ (less than 10(-8) M), these mitochondria release almost all of their stored calcium, whereas chromaffin granules retain the major part of their calcium pool. In the presence of MgATP and at less than 10(-8) M free Ca2+, the mitochondria do not take up significant amounts of Ca2+. Chromaffin granules, however, under the same conditions, show active MgATP-dependent Ca2+ uptake even at nM-concentrations of free Ca2+. The implications of these results for the calcium metabolism of chromaffin cells are discussed.
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