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  • Title: Murine lupus nephritis: effects of cyclophosphamide on circulating and tissue bound immunoreactants.
    Author: Cavallo T, Graves K, Granholm NA.
    Journal: Clin Exp Immunol; 1984 Jan; 55(1):67-73. PubMed ID: 6607142.
    Abstract:
    We investigated the effects of cyclophosphamide (Cy) on immunoreactants of plasma and kidney of mice with lupus nephritis. Cy therapy decreased plasma concentrations of IgG, but not the concentrations of anti-DNA antibodies, C3, and C1q reactive materials; in glomeruli deposits of immunoreactants were mesangial in location and decreased overall. Although Cy arrested the nephritis of NZB/W mice, the anti-DNA activity in the renal eluates was very low and comparable in untreated and in treated mice. Immune complex systems other than, or in addition to, DNA-anti-DNA are likely to play a role in the pathogenesis and course of murine lupus nephritis.
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