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Pubmed for Handhelds

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  • Title: Tripelennamine: enhancement of brain-stimulation reward.
    Author: Unterwald EM, Kucharski LT, Williams JE, Kornetsky C.
    Journal: Life Sci; 1984 Jan 09; 34(2):149-53. PubMed ID: 6607395.
    Abstract:
    Thresholds for reinforcing electrical stimulation to the medial forebrain bundle were determined in rats by means of a rate-free psychophysical method. The acute administration of tripelennamine lowered the threshold for rewarding brain stimulation in a dose-dependent manner. These results suggest that the abuse liability of tripelennamine may be related to its ability to sensitize the central neural pathway that mediates reward.
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