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  • Title: Tight junction structure in relation to transepithelial resistance in the frog choroid plexus.
    Author: von Bülow F, Møllgård K, van Deurs B.
    Journal: Eur J Cell Biol; 1984 Jan; 33(1):90-4. PubMed ID: 6607836.
    Abstract:
    In this communication we report observations on the tight junctions of the frog choroid plexus obtained by thin section and freeze-fracture electron microscopy. It is shown that the choroid plexus epithelial tight junctions comprise a relatively high number (mean 5-6, range 3-10) of continuous, anastomosing strands. This is remarkable in relation to: (1) recent observations that the frog choroidal epithelium has a very low transepithelial resistance, and (2) current concepts of the proportional relationship between transepithelial resistance and number of tight junction strands. It is concluded that there exists a marked lack of correlation between tight junction structure and function in the frog choroid plexus epithelium.
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