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  • Title: Gingival hyperplasia caused by nifedipine--a preliminary report.
    Author: Ramon Y, Behar S, Kishon Y, Engelberg IS.
    Journal: Int J Cardiol; 1984 Feb; 5(2):195-206. PubMed ID: 6607894.
    Abstract:
    We observed marked gingival hyperplasia, similar clinically and histologically to the hyperplasia caused by 5:5 sodium diphenylhydantoin (Dilantin) during the last 18 months in five patients treated by nifedipine. Histologically, marked epithelial hyperplasia-acanthosis, with moderate inflammatory reaction in the lamina propria, was observed in all the biopsy specimens. Evidence points to a strong relationship between the gingival hyperplasia and the administration of nifedipine.
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